Prenatal Programming of Insulin Secretion in Intrauterine Growth Restriction
نویسندگان
چکیده
منابع مشابه
Prenatal programming of insulin secretion in intrauterine growth restriction.
Intrauterine growth restriction (IUGR) impairs insulin secretion in humans and in animal models of IUGR. Several underlying mechanisms have been implicated, including decreased expression of molecular regulators of β-cell mass and function, in some cases shown to be due to epigenetic changes initiated by an adverse fetal environment. Alterations in cell cycle progression contribute to loss of β...
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Intrauterine growth restriction (IUGR) is associated with persistent metabolic complications, but information is limited for IUGR infants. We determined glucose-stimulated insulin secretion (GSIS) and insulin sensitivity in young lambs with placental insufficiency-induced IUGR. Lambs with hyperthermia-induced IUGR (n = 7) were compared with control lambs (n = 8). GSIS was measured at 8 ± 1 days...
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US pregnant uterus 9 Assessment of fetal measurement, growth, amniotic fluid, fetal anatomic survey, and activity patterns is appropriate. O US pregnant uterus biophysical profile 4 Assessment of biophysical profile is of indeterminate appropriateness. Biophysical profile components: 1) fetal heart-rate reactivity; 2) fetal breathing movements; 3) fetal movement; 4) fetal tone; and 5) amniotic ...
متن کاملChronic exposure to elevated norepinephrine suppresses insulin secretion in fetal sheep with placental insufficiency and intrauterine growth restriction.
In this study, we examined chronic norepinephrine suppression of insulin secretion in sheep fetuses with placental insufficiency-induced intrauterine growth restriction (IUGR). Glucose-stimulated insulin secretion (GSIS) was measured with a square-wave hyperglycemic clamp in the presence or absence of adrenergic receptor antagonists phentolamine (alpha) and propranolol (beta). IUGR fetuses were...
متن کاملIntrauterine growth restriction in monochorionic-diamniotic twins.
OBJECTIVE to evaluate neonatal morbidity and mortality in monochorionic-diamniotic (MCDA) twin pregnancies complicated by selective intrauterine growth restriction (sIUGR) and non-selective intrauterine growth resctriction (nsIUGR). METHODS neonatal morbidity parameters and mortality were analyzed in 34 twins with IUGR (< 10th percentile on twins' growth charts): 18 with sIUGR and 16 with nsI...
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ژورنال
عنوان ژورنال: Clinical Obstetrics & Gynecology
سال: 2013
ISSN: 0009-9201
DOI: 10.1097/grf.0b013e31829e5b29